Localization of P2X2 and P2X3 receptors in rat trigeminal ganglion neurons
نویسندگان
چکیده
منابع مشابه
Localization of P2X3 receptors and coexpression with P2X2 receptors during rat embryonic neurogenesis.
It is well known that extracellular ATP mediates rapid excitatory signaling by means of the ionotropic P2X receptors. One of its subunits, the P2X(3) receptor, is well documented to be associated with sensory innervation in adult animals. It is speculated that the P2X(3) receptor may have already been present in the early sensory system. The aim of this study was to investigate the distribution...
متن کاملComparative Analysis of P2X1, P2X2, P2X3, and P2X4 Receptor Subunits in Rat Nodose Ganglion Neurons
Nodose ganglion (NG) neurons are visceral primary sensory neurons. The transmission and regulation of visceral sensation is mediated mainly by the P2X purinoceptor (P2X receptor). Although the characteristics of different P2X receptor subunits in the NG have been studied previously, comprehensive analyses have not been performed. In this study, we used immunohistochemistry, immunocytochemistry,...
متن کاملExpressions of P2X2 and P2X3 receptors in rat nodose neurons after myocardial ischemia injury.
The role of ATP is as a functional neurotransmitter and local intercellular signaling molecule. The nodose neurons express both P2X(2) and P2X(3) subunits in their plasma membrane. This study wants to observe the expression of P2X(2) receptor and the expression relationship between P2X(2) and P2X(3) in nodose neurons after myocardial ischemic injury. The expressions of P2X(3) immunoreactivity, ...
متن کاملFunctional expression of bradykinin B1 and B2 receptors in neonatal rat trigeminal ganglion neurons
Bradykinin (BK) and its receptors (B1 and B2 receptors) play important roles in inflammatory nociception. However, the patterns of expression and physiological/pathological functions of B1 and B2 receptors in trigeminal ganglion (TG) neurons remain to be fully elucidated. We investigated the functional expression of BK receptors in rat TG neurons. We observed intense immunoreactivity of B2 rece...
متن کاملNeutralization of nerve growth factor induces plasticity of ATP-sensitive P2X3 receptors of nociceptive trigeminal ganglion neurons.
The molecular mechanisms of migraine pain are incompletely understood, although migraine mediators such as NGF and calcitonin gene-related peptide (CGRP) are believed to play an algogenic role. Although NGF block is proposed as a novel analgesic approach, its consequences on nociceptive purinergic P2X receptors of trigeminal ganglion neurons remain unknown. We investigated whether neutralizing ...
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ژورنال
عنوان ژورنال: Neuroscience
سال: 2007
ISSN: 0306-4522
DOI: 10.1016/j.neuroscience.2006.09.035